The influence of tremor hyperkinesis on the development of depression in Parkinson's disease and essential tremor (analytical review)

The influence of tremor hyperkinesis on the development of depression in Parkinson's disease and essential tremor (analytical review)

 

Authors

 

V.A. Bogacheva

Federal State Budgetary Institution “V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology” of the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation

D.V. Zakharov

Federal State Budgetary Institution “V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology” of the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation

V.A. Mikhailov

Federal State Budgetary Institution “V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology” of the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation

 

https://doi.org/10.26617/1810-3111-2025-1(126)-98-106

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2025; 1 (126):  98-106.

 

Abstract

Background. The study of the relationship between tremor in Parkinson's disease and the level of depression is dictated by the high prevalence of these conditions in the population as a whole, especially among the elderly. Currently, depression is considered not only as a psychiatric, but also as an important general medical problem, which is determined by its high incidence in the population and association with a number of somatic disorders. Objective: to analyze domestic and foreign literature sources on the effect of tremor hyperkinesis on the development of depression in Parkinson's disease and essential tremor. Results and Discussion. The article shows that depression is a common non-motor symptom among patients with Parkinson's disease and essential tremor. Data are provided on the ability of tremor accompanying these diseases to worsen the quality of life. Tremor causes physical and psychological discomfort, stressful situations when performing simple tasks, negatively affects family relationships, which can potentially lead to depressive states. Data on depression as a premotor manifestation of the disease are presented. The results of a study on the prevalence of reactive depression in patients with resting tremor and a combination of resting tremor and postural/kinetic tremor are discussed. The combination of resting tremor and postural/kinetic tremor in Parkinson's disease worsens clinical indicators, with the prevalence of depression increasing to 28% over 5 years. Higher patient-rated tremor severity, but not physician-rated severity, predicts higher rates of depression. Physician understanding of different types of tremors and their impact on the development of depressive symptoms will help to find effective tools to improve the quality of life of patients with Parkinson's disease.

 

Keywords: Parkinson's disease, depression, essential tremor, tremor hyperkinesis.

 

Article (pdf)

 

Contacts

This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Materials  

For citation: Bogacheva V.A., Zakharov D.V., Mikhailov V.A. The influence of tremor hyperkinesis on the development of depression in Parkinson's disease and essential tremor (analytical review). Siberian Herald of Psychiatry and Addiction Psychiatry.2025; 1 (126): 98-106. https://doi.org/10.26617/1810-3111-2025-1(126)-98-106

REFERENCES

  1. Rukavishnikov GV, Kibitov AO, Mazo GE, Neznanov NG. Genetic determination of comorbidity of depression and somatic diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(1):89-96. https://doi.org/10.17116/jnevro201911901189(in Russian).
  2. Cong S, Xiang C, Zhang S, Zhang T, Wang H, Cong S. Prevalence and clinical aspects of depression in Parkinson's disease: A systematic review and meta‑analysis of 129 studies. Neurosci Biobehav Rev. 2022 Oct;141:104749. https://doi.org/10.1016/j.neubiorev.2022.104749. Epub 2022 Jun 21. PMID: 35750224.
  3. Aarsland D, Brønnick K, Alves G, Tysnes OB, Pedersen KF, Ehrt U, Larsen JP. The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease. J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):928-30. https://doi.org/10.1136/jnnp.2008.166959. PMID: 19608786.
  4. Ng A, Chander RJ, Tan LC, Kandiah N. Influence of depression in mild Parkinson's disease on longitudinal motor and cognitive function. Parkinsonism Relat Disord. 2015 Sep;21(9):1056-60. https://doi.org/10.1016/j.parkreldis.2015.06.014. Epub 2015 Jun 18. PMID: 26117438.
  5. Chagas MHN, Tumas V, Pena-Pereira MA, Machado-de-Sousa JP, Carlos Dos Santos A, Sanches RF, Hallak JEC, Crippa JAS. Neuroimaging of major depression in Parkinson's disease: Cortical thickness, cortical and subcortical volume, and spectroscopy findings. J Psychiatr Res. 2017 Jul;90:40-45. https://doi.org/10.1016/j.jpsychires.2017.02.010. Epub 2017 Feb 13. PMID: 28222355.
  6. Thobois S, Ardouin C, Lhommée E, Klinger H, Lagrange C, Xie J, Fraix V, Coelho Braga MC, Hassani R, Kistner A, Juphard A, Seigneuret E, Chabardes S, Mertens P, Polo G, Reilhac A, Costes N, LeBars D, Savasta M, Tremblay L, Quesada JL, Bosson JL, Benabid AL, Broussolle E, Pollak P, Krack P. Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation. Brain. 2010 Apr;133(Pt 4):1111-27. https://doi.org/10.1093/brain/awq032. Epub 2010 Mar 17. PMID: 20237128.
  7. Seritan AL, Rienas C, Duong T, Delucchi K, Ostrem JL. Ages at onset of anxiety and depressive disorders in parkinson's disease. J Neuropsychiatry Clin Neurosci. 2019 Fall;31(4):346-352. https://doi.org/10.1176/appi.neuropsych.18090201. Epub 2019 May 23. PMID: 31117906.
  8. Marras C, Chaudhuri KR. Nonmotor features of Parkinson's disease subtypes. Mov Disord. 2016 Aug; 31(8):1095-102. https://doi.org/10.1002/mds.26510. Epub 2016 Feb 10. PMID: 26861861.
  9. Shalash AS, Hamid E, Elrassas H, Bahbah EI, Mansour AH, Mohamed H, Elbalkimy M. Non-motor symptoms in essential tremor, akinetic rigid and tremor-dominant subtypes of Parkinson's disease. PLoS One. 2021 Jan 27;16(1):e0245918. https://doi.org/10.1371/journal.pone.0245918. PMID: 33503062; PMCID: PMC7840014.
  10. Wang J, Shen Y, Peng J, Wang A, Wu X, Chen X, Liu J, Wei M, Zou D, Han Y, Cheng O. Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson's disease. Neurol Sci. 2021 Jul;42(7):2937-2946. https://doi.org/10.1007/s10072-020-04917-1. Epub 2020 Nov 24. PMID: 33236247.
  11. Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008 Apr; 79(4): 368-76. https://doi.org/10.1136/jnnp.2007.131045. PMID: 18344392.
  12. Moretti R, Milner V, Caruso P, Gazzin S, Rumiati R. Frontal tasks and behavior in rigid or tremor-dominant parkinson disease. Am J Alzheimers Dis Other Demen. 2017 Aug;32(5):300-306. https://doi.org/10.1177/1533317517714887. Epub 2017 Jun 14. PMID: 28612623; PMCID: PMC10852814.
  13. Louis ED, Machado DG. Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients. Parkinsonism Relat Disord. 2015 Jul; 21(7): 729-35. https://doi.org/10.1016/j.parkreldis.2015.04.019. Epub 2015 Apr 24. PMID: 25952960; PMCID: PMC4764063.
  14. Dai HD’, Angelo LT. Quantitative assessment of tremor during deep brain stimulation using a wearable glove system. In: IEEE International Conference on Sensing, Communications and Networking (SECON). Conference Location. New Orleans, LA, USA 2013. https://doi.org/10.1109/SAHCN.2013.6644965.
  15. Luo L, Andrews H, Alcalay RN, Poyraz FC, Boehme AK, Goldman JG, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Sutherland M, Kopil C, Naito A, Kang UJ. Motor phenotype classification in moderate to advanced PD in BioFIND study. Parkinsonism Relat Disord. 2019 Aug;65:178-183. https://doi.org/10.1016/j.parkreldis.2019.06.017. Epub 2019 Jun 23. PMID: 31255537; PMCID: PMC6774826.
  16. Pasquini J, Ceravolo R, Qamhawi Z, Lee JY, Deuschl G, Brooks DJ, Bonuccelli U, Pavese N. Progression of tremor in early stages of Parkinson's disease: a clinical and neuroimaging study. Brain. 2018 Mar 1;141(3):811-821. https://doi.org/10.1093/brain/awx376. PMID: 29365117.
  17. Levin OS, Fedorova NV. Parkinson's disease. 5th edition. Moscow: MEDpress-inform Publishing House, 2015:384 (in Russian).
  18. Golubev VL. Diagnostics and therapy of the tremor form of Parkinson's disease. In: Parkinson's disease and movement disorders / SN Illarioshkin, NN Yakhno, eds. Section 4. Clinical manifestations of Parkinson's disease. Quality of life issues. Moscow: Dialog Publishing House, 2008:85-88 (in Russian).
  19. Bogacheva VA, Zakharov DV, Mikhailov VA, Shubina YuV. Quality of life of patients with tremor form of Parkinson's disease. V.M. Bekhterev Review of Psychiatry and Medical Psychology. 2015;1:33-37. https://doi.org/10.31363/2313-7053-2022-56-2-35-41 (in Russian).
  20. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Sleep disorders in essential tremor: systematic review and meta-analysis. Sleep. 2020 Sep 14;43(9):zsaa039. https://doi.org/10.1093/sleep/zsaa039. PMID: 32163585.
  21. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Sleep disorders in patients with essential tremor. Curr Neurol Neurosci Rep. 2021 Mar 22;21(5):23. https://doi.org/10.1007/s11910-021-01109-y. PMID: 33754217.
  22. Shang Y, Chen X, Ai M, Gao X, Dai S, Zhao M, Yang C, Wang L, Zhang J, Zhong L, Bao T, Liu X. Association of essential tremor with dementia and affective disorders: A meta-analysis. Front Neurol. 2022 Mar 17;13:842732. https://doi.org/10.3389/fneur.2022.842732. PMID: 35370922; PMCID: PMC8967984.
  23. Shalash AS, Mohamed H, Mansour AH, Elkady A, Elrassas H, Hamid E, Elbalkimy MH. Clinical profile of non-motor symptoms in patients with essential tremor: Impact on quality of life and age-related differences. Tremor Other Hyperkinet Mov (N Y). 2019 Dec 6;9. https://doi.org/10.7916/tohm.v0.736. PMID: 31867132; PMCID: PMC6898893.
  24. Chandran V, Pal PK, Reddy JY, Thennarasu K, Yadav R, Shivashankar N. Non-motor features in essential tremor. Acta Neurol Scand. 2012 May;125(5):332-7. https://doi.org/10.1111/j.1600-0404.2011.01573.x. Epub 2011 Jul 20. PMID: 21777207.
  25. Papapetropoulos S, Ellul J, Argyriou AA, Chroni E, Lekka NP. The effect of depression on motor function and disease severity of Parkinson's disease. Clin Neurol Neurosurg. 2006 Jul;108(5):465-9. https://doi.org/10.1016/j.clineuro.2005.08.002. Epub 2005 Sep 16. PMID: 16150537.
  26. Fields JA, Tröster AI, Woods SP, Higginson CI, Wilkinson SB, Lyons KE, Koller WC, Pahwa R. Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor. J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):305-11. https://doi.org/10.1136/jnnp.74.3.305. PMID: 12588913; PMCID: PMC1738322.
  27. Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schäfer H, Bötzel K, Daniels C, Deutschländer A, Dillmann U, Eisner W, Gruber D, Hamel W, Herzog J, Hilker R, Klebe S, Kloss M, Koy J, Krause M, Kupsch A, Lorenz D, Lorenzl S, Mehdorn HM, Moringlane JR, Oertel W, Pinsker MO, Reichmann H, Reuss A, Schneider GH, Schnitzler A, Steude U, Sturm V, Timmermann L, Tronnier V, Trottenberg T, Wojtecki L, Wolf E, Poewe W, Voges J; German Parkinson Study Group, Neurostimulation Section. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med. 2006 Aug 31;355(9):896-908. https://10.1056/NEJMoa060281. Erratum in: N Engl J Med. 2006 Sep 21;355(12):1289. PMID: 16943402.
  28. Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ Jr, Rothlind J, Sagher O, Reda D, Moy CS, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein J, Stoner G, Heemskerk J, Huang GD; CSP 468 Study Group. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009 Jan 7;301(1):63-73. https://doi.org/10.1001/jama.2008.929. PMID: 19126811; PMCID: PMC2814800.
  29. Daniels C, Krack P, Volkmann J, Raethjen J, Pinsker MO, Kloss M, Tronnier V, Schnitzler A, Wojtecki L, Bötzel K, Danek A, Hilker R, Sturm V, Kupsch A, Karner E, Deuschl G, Witt K. Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable? Mov Disord. 2011 Dec;26(14):2516-21. https://doi.org/10.1002/mds.23907. Epub 2011 Aug 25. PMID: 22170276.
  30. Smeding HM, Speelman JD, Huizenga HM, Schuurman PR, Schmand B. Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson's Disease. J Neurol Neurosurg Psychiatry. 2011 Jul; 82(7):754-60. https://doi.org/10.1136/jnnp.2007.140012. Epub 2009 May 21. PMID: 19465417.
  31. Fasano A, Romito LM, Daniele A, Piano C, Zinno M, Bentivoglio AR, Albanese A. Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants. Brain. 2010 Sep;133(9):2664-76. https://doi.org/10.1093/brain/awq221. PMID: 20802207.
  32. Achey RL, Yamamoto E, Sexton D, Hammer C, Lee BS, Butler RS, Thompson NR, Nagel SJ, Machado AG, Lobel DA. Prediction of depression and anxiety via patient-assessed tremor severity, not physician-reported motor symptom severity, in patients with Parkinson's disease or essential tremor who have undergone deep brain stimulation. J Neurosurg. 2018 Dec 1;129(6):1562-1571. https://doi.org/10.3171/2017.8.JNS1733. Epub 2018 Feb 23. PMID: 29473781.